The agent continues to work to liberate city districts and eventually manages to find and rescue Ellis from Hyena custody. Kelso is reluctant to waste time and resources to rescue Ellis, but Ortega points out that his security clearance may be needed to access the cure. Meanwhile, Ortega and Kelso uncover information that a cure to Green Poison might be located somewhere in the city, and that President Ellis may have survived the crash of Air Force One and is being held by one of the city's factions. Ortega instructs the agent to work with fellow agent Alani Kelso to help assist civilian settlements, fight the various enemy groups, and restore the SHD Network. The agent learns that much of the city is under the control of three main enemy factions: the Hyenas, a loosely organized group of several gangs, criminals, and anarchists who seek to take advantage of the chaos, the Outcasts, a fanatical group made up of the survivors of the Roosevelt Island quarantine zone, whom seek to exact revenge on those they believe responsible for their imprisonment and eventual infection, and the True Sons, a highly organized and ruthless group of former Joint Task Force personnel, paramilitaries, and other traitors who seek to gain control over the entire capital. After defeating an attack on the White House shortly after arriving in the city, the agent is briefed on the general situation by Manny Ortega, The Division Coordinator for D.C.
The player’s agent makes their way to the city where The Division and the remains of the local Joint Task Force have set up their Base of Operations in the White House. In the middle of the attack, the SHD Network, the system controlling their advanced technology and communications, suddenly shuts down, and they receive a Division distress call from Washington, D.C. Seven months after the Green Poison outbreak, several Division agents are defending a civilian settlement from a bandit attack.